Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...
Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...
Researchers at the MRC Laboratory of Medical Sciences (LMS) and collaborators have uncovered one of the earliest steps in DNA replication: the moment a cell first opens its DNA to begin making a copy ...
Doctors currently assess these biopsies by eye using a staining technique that is more than a century old. The new approach, ...
Researchers at The University of Texas MD Anderson Cancer Center have developed a new imaging method, known as RF-SIRF, that quantitatively detects and maps reversed DNA replication forks with ...
A new atlas pairs DNA methylation with 3D genome folding in 86,689 human cells and ties disease risk to specific cell types.
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Scientists discover hidden layer of RNA that helps fine-tune how tightly DNA coils itself
Scientists have identified a previously unrecognized layer of the human genome. It’s built not ...
Scientists long believed tardigrades survived lethal radiation by masterfully rebuilding their destroyed DNA, but new ...
A representative figure showing that HELQ-deficient cells fail to undergo normal fork slowing after MMC (a crosslinking agent) treatment, consistent with defective fork reversal. Every time a cell ...
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