A molecular illustration of the crowded interior and cell envelope of Escherichia coli. (David S. Goodsell, The Scripps ...

Eukaryotic DNA replication is initiated at multiple origins through a tightly regulated sequence of events: origin licensing, helicase activation and assembly of the replisome. The replicative ...

Every human's genome has millions of genetic variants, but most have little to no effect, making it difficult for clinicians to make medical diagnoses based on genetic differences. Using patterns of ...

Researchers have gained a clearer insight into how common alterations to the structure of DNA affect the process of DNA replication. These structural changes can put a stop to replication, causing ...

Researchers have used AI to uncover the DNA signature of a key genetic “switch” involved in turning genes on. After analyzing ...

From the Bedalov Lab, Translational Science and Therapeutics and Human Biology Divisions When I asked Foss and Bedalov whether the known replication origins in yeast shared any sequence-level features ...

Nearly every cell in the human body contains essentially the same genetic information, yet different cells activate different genes. For regulatory proteins to reach these genes, DNA must be ...

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...

Scheme showing the structure of cytosine, 5-methylcytosine, and 5-hydroxymethylcytosine. Adding a methyl group to the DNA base cytosine represses gene expression in mammalian cells. To remove the ...

Zettabytes—that’s 10 21 bytes—of data are currently generated every year. All of those cat videos have to be stored somewhere, and DNA is a great storage medium; it has amazing data density and is ...