The mammalian target of rapamycin (mTOR) protein, a member of the phosphoinositide 3-kinase (PI3K)-related protein kinase (PIKK) family, has a central role in two growth-regulatory pathways that have ...

The mechanistic target of rapamycin (mTOR) pathway coordinates cell growth, metabolism and synaptic plasticity in the central nervous system. Dysregulation of mTOR signalling, often through mutations ...

A newly published study in Genes & Diseases highlights the crucial role of the mammalian target of rapamycin (mTOR) pathway in the progression of diabetic nephropathy (DN) and explores its potential ...

Prognostic value of hedgehog signaling in cervical carcinoma. Background: Although improvements in the treatment of ovarian cancer have increased the global prognosis, the metastatic disease is still ...

Network map of 29 authors with frequency greater than five. Nodes represent authors, and the larger the node, the higher the number of papers. The lines represent collaborations with other authors, ...

Oncotarget published "Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the ...

First-in-human phase I study exploring three schedules of OSI-027, a novel small molecule TORC1/TORC2 inhibitor, in patients with advanced solid tumors and lymphoma. A phase I study of the oral mTOR ...