The biologic treatments approved for the management of severe asthma have transformed the outlook for patients over the past decade. Each novel therapy has offered the opportunity for oral ...

The management of advanced hepatocellular carcinoma, defined by the presence of vascular invasion, extrahepatic spread, and ...

The health of LGBTQ+ people has long been an indicator of wider advances in human rights and health equity. Modern LGBTQ+ ...

Nearly three decades after the discovery of the orexin (also known as hypocretin) neuropeptides and the identification of orexin deficiency as the cause of narcolepsy type 1,1 orexin 2 receptor (OX2R) ...

It has been 40 years since Purdue Pharma released OxyContin in the USA and—through its aggressive marketing, lobbying, and ...

The global humanitarian crisis is escalating due to conflicts, climate-related disasters, and infection outbreaks.1 Recent ...

In February, 2025, we reported in The Lancet the human toll of the UK's prolonged refusal to introduce newborn screening for spinal muscular atrophy, despite overwhelming international evidence ...

For the past four decades, oral antiretroviral therapy for HIV has required daily doses. Long-acting injectable cabotegravir ...

We call it le Vidal”, Alexandre Loupy says. “It's a 4000-page book that my mother had, with all the medications…I said, okay, ...

The declaration on July 28, 2026, that the Bundibugyo virus outbreak in Uganda had ended marks a crucial milestone in outbreak control.1 WHO considers an Ebola outbreak resolved 42 consecutive days ...

My doctor told me to lose weight.” As a paediatrician and adolescent medicine specialist practising in the USA with a specialty in eating disorders, I hear a version of this sentence frequently when I ...

Despite decades of health-care digitalisation efforts worldwide, health information systems remain highly fragmented, with ...