When the causal mutation is known, the challenge shifts from identifying disease origins to defining its detectable beginning ...

Background Autosomal dominant Alzheimer’s disease (ADAD) serves as a model for presymptomatic biomarker discovery.

1 University of Pittsburgh School of Medicine, Department of Otolaryngology 2 University of Pittsburgh School of Medicine, Department of Psychiatry 3 University of Pittsburgh School of Medicine, ...

Background Cerebellar ataxias are the result of diverse disease processes that can be genetic or acquired. Establishing a diagnosis requires a methodical approach with expert clinical evaluation and ...

Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA Dr K C Gorson, Department of Neurology, Caritas St Elizabeth’s Medical Center, 736 Cambridge ...

Background To characterise the response to treatment of inaugural optic neuritis (ON) in patients with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). Methods We searched the ...

OBJECTIVES The detection of the protein 14–3–3 in the CSF has been shown to be a reliable and sensitive marker for sporadic Creutzfeldt-Jakob disease (CJD). Other brain-specific proteins such as ...

Objectives: Gait and mobility problems are difficult to treat in people with Parkinson’s disease. The Rehabilitation in Parkinson’s Disease: Strategies for Cueing (RESCUE) trial investigated the ...

Objective: To study the safety and efficacy of the cholinesterase inhibitor donepezil in patients with Parkinson's disease (PD) and cognitive impairment. Methods: This was a double blind, randomised ...

Helen Durham Neuro-inflammatory Centre, Department of Neurology, University Hospital of Wales, Heath Park, Cardiff, UK Background: Detailed studies of mortality in multiple sclerosis (MS) are limited.

Department of Neurology, Walton Centre for Neurology and Neurosurgery, Rice Lane, Liverpool, UK Dr PRD Humphrey, Department of Neurology, Walton Centre for Neurology and Neurosurgery, Rice Lane, ...

1 Department of Neurology, National Institute of Mental Health & Neurosciences, Bangalore, India 2 Department of Neuropathology, National Institute of Mental Health & Neurosciences, Bangalore, India 3 ...