The expanded CAG repeat that causes HD sits within the very beginning of the huntingtin gene. Sometimes the huntingtin ...

A new Phase 1 study is testing SRP-1005, a huntingtin-lowering therapy given by injection under the skin. It’s early days, ...

We’re pleased to announce the 2026 HDBuzz Prize! This year, the HDBuzz Prize is brought to you by the Hereditary Disease ...

Day 3 of #HD2026 put HTT under the microscope. Researchers shared new insights into HTT1a, next-generation HTT-lowering ...

This week, HDBuzz is attending the HD2026 Milton Wexler Biennial Symposium in Boston, Massachusetts. Held every other year and organized by the Huntington’s Disease Foundation (HDF), this conference ...

Roche’s announcement that they were ending two of their HD programs was genuinely disappointing, and it leaves behind some unanswered questions. Was huntingtin lowered enough in the brain regions that ...

Today, Roche announced in a community letter difficult news for the Huntington’s disease (HD) community, discontinuing two separate clinical programmes after new data emerged from ongoing studies. The ...

In plain language. Written by scientists. #Buzzilia, day 4: Jeff and Ed's roundup of happenings from the closing day of the HD World Congress in Rio de Janeiro #Buzzilia, day 3: Jeff and Ed's roundup ...

uniQure shared in a press release on June 17, 2026 that the Food and Drug AdministrationFood and Drug Administration The government regulatory authority in the US responsible for approving new drugs ...

Huntington’s disease (HD) involves the loss of cells in the striatum, an area of the brain that plays important roles in movement, cognition, and behaviour. For decades, researchers have been ...

Last year, 329,000 people visited HDBuzz. They came after a clinical trialclinical trial Very carefully planned experiments designed to answer specific questions about how a drug affects human beings ...

A new study shows that lowering a harmful piece of the huntingtin message (Htt1a) appears effective at reducing HD-related symptoms in mice, perhaps more so than targeting full length HTTHTT one ...