Risk stratification in compensated advanced chronic liver disease has traditionally been based on the identification of ...

Diambra and colleagues1 integrated metabolic dysfunction-associated steatotic liver disease phenotypes with proteomics to derive a four-protein mortality score (PS4: FTCD, FABP1, ADGRG1 and GAST). We ...

Snijkers and colleagues should be congratulated for completing a multicentre, three-arm randomised trial of gut-directed ...

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Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition where overlapping cardiometabolic risk factors challenge accurate prognostic prediction.

Background The liver naturally exhibits robust glycosylation processes, yet how aberrant glycosylation affects hepatocellular carcinoma (HCC) and its underlying mechanisms remains poorly understood.

Background Fistulising perianal Crohn’s disease (CD) remains a debilitating condition, with few randomised controlled trials conducted so far. Objective To evaluate the efficacy and safety of ...

Background New-onset diabetes (NOD) increases the risk of pancreatic cancer. Previous studies have mainly focused on the presence or absence of diabetes, with limited attention to NOD severity at ...

We would like to thank von Muhlenbrock et al for their letter1 and for their interest in our recent network meta-analysis.2 Some gut-brain neuromodulators, particularly tricyclic antidepressants (TCAs ...

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Background Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction, with some recommended treatments targeting brain-gut axis dysfunction. Objective To compare relative efficacy of ...

I read the GOULASH trial with great interest. This multicentre, double-blind randomised clinical trial compared early high-energy enteral nutrition (30 kcal/kg/day) with a gradually increasing energy ...